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    Title: Alteration in the expression of protein kinase C isoforms in human hepatocellular carcinoma.
    Authors: Jen-Hsiang Tsai;Yih-Shou Hsieh;Shou-Jen Kuo;Shou-Tung Chen;Shi-Yau Yu;Chih-Yang Huang;Ai-Chi Chang;Yi-Wei Wang;Min-Ting Tsai;Jer-Yuh Liu
    Contributors: 輔英科技大學 物理治療系
    Keywords: Human hepatocellular carcinoma;Protein kinase C isoforms;Protein kinase C activity
    Date: 2000-12-01
    Issue Date: 2010-11-10 09:42:42 (UTC+8)
    Abstract: This study was designed to investigate the alterations of individual protein kinase C (PKC) isoforms in human liver cancer. Surgical specimens of hepatocellular carcinoma and adjacent normal tissues were extracted into cytosolic and membranous fractions. The level of membrane-bound PKCα in the cancer tissue was significantly lower than that in the adjacent normal tissue and consistent with the change in PKC activity. In addition, there was a significant negative correlation between PKCα and tumor size. In both cytosolic and membrane fractions, levels of PKCδ and PKCζ was significantly higher in the cancer tissue than those in the adjacent normal liver tissue. The alterations in the PKC isoforms signify their roles in the hyperproliferation in liver cancer.
    Relation: Cancer Letters 161(2),171-175
    Appears in Collections:[Department of Physical Technology] Journal Article

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