Fooyin University Institutional Repository:Item 987654321/9732
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    Title: Antiplatelet and calcium inhibitory properties of eugenol and sodium eugenol acetate.
    Authors: Chen, S.J.;Wang, M.H.;Chen, I.J.
    Contributors: 輔英科技大學 健康美容學位學程
    Date: 1997-06-01
    Issue Date: 2010-11-14 10:09:50 (UTC+8)
    Abstract: 1. Eugenol (3-methoxy-4-hydroxy-propenylbenzene) or sodium eugenol acetate (4-O-acetic acid sodium-3-methoxy-1-propenylbenzene) (0.25, 0.5, 1 mM) concentration-dependently inhibited arachidonic acid (AA)-, collagen-, epinephrine- and ADP-induced platelet aggregation. 2. Eugenol or sodium eugenol acetate inhibited collagen-induced aggregation of washed rabbit platelets synergistically with creatine phosphate/creatine phosphokinase (CP/CPK, 5 mM/10 U/ml) or p-bromophenacyl bromide (p-BPB, 10 microM), and they also potentiated the inhibitory action of imidazole (0.5 mM) on AA-induced aggregation. 3. Eugenol or sodium eugenol acetate (0.25, 0.5, 1 mM) concentration-dependently inhibited AA-induced thromboxane B2 and prostaglandin E2 formation. 4. The rise of intracellular Ca2+ caused by collagen, epinephrine, ADP, and AA were inhibited by eugenol or sodium eugenol acetate (1 mM).
    Relation: Gen Pharmacol.27(4):629-633
    Appears in Collections:[Bachelor Degree Program of Health Beauty] Journal Article

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